Selected journal articles


* Barreda trainees shown in bold.

  1. More Bayona JA, Karuppannan AK, Barreda DR. (2017) Contribution of leukocytes to the induction and resolution of the acute inflammatory response in chickens Developmental and Comparative Immunology Sep;74:167-177. doi: 10.1016/j.dci.2017.04.018. Epub 2017 Apr 26.  LINK
  2. Havixbeck JJ, Rieger AM, Churchill LJ, Barreda DR*. (2017) Neutrophils exert protection in early Aeromonas veronii infections through the clearance of both bacteria and dying macrophages. Fish and Shellfish Immunology;63:18-30 LINK
  3. Trites MJ, Barreda DR*. (2017) Contributions of transferrin to acute inflammation in the goldfish, auratus. Developmental and Comparative Immunology 67:300-309. LINK
  4. More Bayona JA, Karuppannan AK, Trites MJ, Barreda DR*. (2017) Application of imaging flow cytometry for characterization of acute inflammation in non-classical animal model systems. Methods. 112: 167-174. LINK
  5. Tierney KB*, Welsh PO, Mills M, Nason S, Barreda DR, Paszkowski CA (2016) Mallards (Anas platyr-hynchos) and wastewater ponds: Developmental, physiological, morphological, and behavioural effects of ingestion of secondary clarified effluent water. Ecotoxicology and Environmental Safety. 2017 Sep;143:336-343. LINK
  6. Abós B, Wang T, Castro R, Granja AG, Leal E, Havixbeck J, Luque A, Barreda DR, Secombes CJ, Tafalla C*. (2016) Distinct differentiation programs triggered by IL-6 and LPS in teleost IgM(+) B cells in the absence of germinal centers. Scientific Reports 6:30004. LINK
  7. Rieger AM, Barreda DR*. (2016) Accurate assessment of cell death by imaging flow cytometry. Methods in Molecular Biology 1389:209-20. LINK
  8. Havixbeck JJ, Rieger AM, Wong ME, Hodgkinson JW, Barreda DR*. (2016) Leading Edge Research: Neutrophil contributions to the induction and regulation of the acute inflammatory response in teleost fish. Journal of Leukocyte Biology. 2016 99(2):241-52. Editorial Featured Article. LINK
  9. Haisan J, Sun Y, Guan LL, Beauchemin KA, Iwaasa A, Duval S, Kindermann M, Barreda DR, Oba M*. (2016) The effects of feeding 3-nitrooxypropanol at two doses on milk production, rumen fermentation, plasma metabolites, nutrient digestibility, and methane emissions in lactating Holstein cows. Animal Production Science. 57: 282-289. LINK
  10. Havixbeck JJ, Barreda DR*. (2015) Neutrophil development, migration, and function in teleost fish. Biology (Basel) 4(4):715-34. LINK
  11. Hodgkinson JW, Ge JQ, Katzenback BA, Havixbeck JJ, Barreda DR, Stafford JL, Belosevic M*. (2015) Development of an in vitro model system to study the interactions between Mycobacterium marinum and teleost neutrophils. Developmental and Comparative Immunology 53(2):349-57. LINK
  12. Rieger AM, Havixbeck JJ, Barreda DR*. (2015) X-FISH: Analysis of cellular RNA expression patterns using flow cytometry. Journal of Immunological Methods. 423:111-9. LINK
  13. Havixbeck JJ, Wong ME, More Bayona JA, Barreda DR*. (2015) Multi-parametric analysis of phagocyte antimicrobial responses using imaging flow cytometry. Journal of Immunological Methods 423:85-92. LINK
  14. Singh A, Havixbeck JJ, Smith MK, Shu Z, Tierney KB, Barreda DR, El-Din MG, Belosevic M*. (2015) UV and hydrogen peroxide treatment restores changes in innate immunity caused by exposure of fish to reuse water. Water Research 71:257-73.  LINK
  15. Rieger AM, Havixbeck JJ, Belosevic M, Barreda DR*. (2015) Teleost soluble CSF-1R modulates cytokine profiles at an inflammatory site, and inhibits neutrophil chemotaxis, phagocytosis, and bacterial killing. Developmental and Comparative Immunology 49(2):259-66. LINK
  16. Abós B, Castro R, González Granja A, Havixbeck JJ, Barreda DR, Tafalla C*. (2015) Early activation of teleost B cells in response to rhabdovirus infection. Journal of Virology 89(3):1768-80. LINK
  17. Havixbeck JJ, Rieger AM, Wong ME, Wilkie MP, Barreda DR*. (2014) Evolutionary conservation of divergent pro-inflammatory and homeostatic responses in Lamprey phagocytes. PLoS One 9(1):e86255. LINK
  18. Duquette SC, Fischer CD, Feener TD, Muench GP, Morck DW, Barreda DR, Nickerson JG, Buret AG*. (2014) Anti-inflammatory effects of retinoids and carotenoid derivatives on caspase-3-dependent apoptosis and efferocytosis of bovine neutrophils. American Journal of Veterinary Research 75(12):1064-75. LINK
  19. Nagasawa T, Nakayasu C, Rieger AM, Barreda DR, Somamoto T, Nakao M*. (2014) Phagocytosis by thrombocytes is a conserved innate immune mechanism in lower vertebrates. Frontiers in Immunology 5:445. LINK
  20. Moon TC, Campos-Alberto E, Yoshimura T, Bredo G, Rieger AM, Puttagunta L, Barreda DR, Befus AD, Cameron L*. (2014) Expression of DP2 (CRTh2), a prostaglandin D₂ receptor, in human mast cells. PLoS One 9(9):e108595. LINK
  21. Chang JP, Sawisky GR, Davis PJ, Pemberton JG, Rieger AM, Barreda DR*. (2014) Relationship between nitric oxide- and calcium-dependent signal transduction pathways in growth hormone release from dispersed goldfish pituitary cells. General and Comparative Endocrinology 206:118-29. LINK
  22. Rieger AM, Hanington PC, Belosevic M, Barreda DR*. (2014) Control of CSF-1 induced inflammation in teleost fish by a soluble form of the CSF-1 receptor. Fish and Shellfish Immunology 41(1):45-51. LINK
  23. Barreda DR*,  Konowalchuk JD, Rieger AM, Wong ME, Havixbeck JJ. (2014) Triennial Growth Symposium – Novel roles for vitamin D in animal immunity and health. Journal of Animal Science 92(3):930-8. LINK
  24. Haisan J, Sun Y, Guan LL, Beauchemin KA, Iwaasa A, Duval S, Barreda DR, Oba M*. (2014) The effects of feeding 3-nitrooxypropanol on methane emissions and productivity of Holstein cows in mid lactation. Journal of Dairy Science. 97(5):3110-9. LINK
  25. Elsaidi HR, Barreda DR, Cairo CW, Lowary TL*. (2013) Mycobacterial phenolic glycolipids with a simplified lipid aglycone modulate cytokine levels through Toll-like receptor 2. Chembiochem 14(16):2153-9. LINK
  26. Albornoz RI, Aschenbach JR, Barreda DR, Penner GB*. (2013) Feed restriction reduces short-chain fatty acid absorption across the reticulorumen of beef cattle independent of diet. Journal of Animal Science 91(10):4730-8. LINK
  27. Albornoz RI, Aschenbach JR, Barreda DR, Penner GB*. (2013) Moderate decreases in the forage-to-concentrate ratio before feed restriction and increases thereafter independently improve the recovery from a feed restriction insult in beef cattle. Journal of Animal Science 91(10):4739-49. LINK
  28. Konowalchuk JD, Rieger AM, Kiemele MD, Ayres DC, Barreda DR*. (2013) Modulation of weanling pig cellular immunity in response to diet supplementation with 25-hydroxyvitamin D(3). Veterinary Immunology and Immunopathology 155(1-2):57-66. LINK
  29. Zhang S, Albornoz RI, Aschenbach JR, Barreda DR, Penner GB*. (2013) Short-term feed restriction impairs the absorptive function of the reticulo-rumen and total tract barrier function in beef cattle. Journal of Animal Science 91(4):1685-95. LINK
  30. Zhang S, Aschenbach JR, Barreda DR, Penner GB*. (2013) Recovery of absorptive function of the reticulo-rumen and total tract barrier function in beef cattle after short-term feed restriction. Journal of Animal Science 91(4):1696-706. LINK
  31. Rieger AM, Konowalchuk JD, Havixbeck JJ, Robbins JS, Smith MK, Lund JM, Barreda DR*. (2013) A soluble form of the CSF-1 receptor contributes to the inhibition of inflammation in a teleost fish. Developmental and Comparative Immunology 39(4):438-46. LINK
  32. Rieger AM, Konowalchuk JD, Grayfer L, Katzenback BA, Havixbeck JJ, Kiemele MD, Belosevic M, Barreda DR*. (2012) Fish and mammalian phagocytes differentially regulate pro-inflammatory and homeostatic responses in vivo. PLoS One 7(10):e47070. LINK
  33. Parra D, Rieger AM, Li J, Zhang YA, Randall LM, Hunter CA, Barreda DR, Sunyer JO*. (2012) Pivotal advance: peritoneal cavity B-1 B cells have phagocytic and microbicidal capacities and present phagocytosed antigen to CD4+ T cells. Journal of Leukocyte Biology. 91(4):525-36. Editorial Featured Article. LINK
  34. Hamidu JA, Uddin Z, Li M, Fasenko GM, Guan LL, Barreda DR*. (2011) Broiler egg storage induces cell death and influences embryo quality. Poultry Science 90(8):1749-57. LINK
  35. Rieger AM, Nelson KL, Konowalchuk JD, Barreda DR*. (2011) Modified annexin V/propidium iodide apoptosis assay for accurate assessment of cell death. Journal of Visualized Experiments 50 pii: 2597. LINK
  36. Rieger AM, Barreda DR*. (2011) Antimicrobial mechanisms of fish leukocytes. Developmental and Comparative Immunology 35(12):1238-45. LINK
  37. Hamidu JA, Fasenko GM, Guan LL, Barreda DR, and Feddes JJR*. (2011) Influence of parent flock age on embryonic metabolism in modern turkey strains. Poultry Science 90(2): 426-34. LINK
  38. Rieger AM, Hall BE, Barreda DR*. (2010) Macrophage activation differentially modulates particle binding, phagocytosis and downstream antimicrobial mechanisms. Developmental and Comparative Immunology 34(110): 1144-59. LINK
  39. Rieger AM, Hall BE, Luong le T, Schang LM, Barreda DR* (2010) Conventional apoptosis assays using propidium iodide generate a significant number of false positives that prevent accurate assessment of cell death. Journal of Immunological Methods 358(1-2): 81-92. LINK
  40. Hamidu JA, Rieger AM, Fasenko GM, Barreda DR* (2010) Dissociation of chicken blastoderm for examination of apoptosis and necrosis by flow cytometry. Poultry Science 89(5): 901-9. LINK
  41. Khaniya B, Almeida L, Basu U, Taniguchi M, Williams JL, Barreda DR, Moore SS, Guan LL*. (2009) Microarray analysis of differentially expressed genes from Peyer’s patches of cattle orally challenged with bovine spongiform encephalopathy. Journal of Toxicology and Environmental Health Part A 72(17): 1008-13. LINK
  42. Hanington PC, Tam J-Y, Katzenback BA, Hitchen SJ, Barreda DR, Belosevic M*. (2009) Development of macrophages of cyprinid fish. Developmental and Comparative Immunology 33(4): 411-29. LINK
  43. Walsh JG, Barreda DR, Belosevic M* (2007) Cloning and expression analysis of goldfish (Carassius auratus ) prominin. Fish and Shellfish Immunology 22: 308-317.LINK
  44. Li J., Barreda DR, Zhang YA, Boshra H, Gelman AE, Lapatra S, Tort L, Sunyer JO*. (2006). Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis.Journal of Leukocyte Biology2006 Dec;80(6):1553-62 LINK
  45. B-lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities. Nature Immunology 7(10): 1116-24. Cover article. LINK
  46. Huang Z-Y, Barreda DR, Worth RG, Kim M-K, Chien P, Indik ZK, Schreiber AD*. (2006) Differential role for SRTK, Syk, and PI3 kinase in human and mouse Fc-gamma receptor phagocytosis and endocytosis. Journal of Leukocyte Biology 80(6): 1553-62. LINK
  47. Hanington PC, Barreda DR, Belosevic M*. (2006) A novel hematopoietic granulin induces proliferation of goldfish (Carassius auratus ) macrophages. Journal of Biological Chemistry 14; 281(15): 9963-70. LINK
  48. Belosevic M*, Hanington PC, and Barreda DR (2006) Development of goldfish macrophages in vitro. Fish and Shellfish Immunology 20(2): 152-171. LINK
  49. Barreda DR, Hanington PC, Stafford JL, Belosevic M* (2005) A novel soluble form of the CSF-1 receptor inhibits proliferation of self-renewing fish macrophages. Developmental and Comparative Immunology 29(10): 879-894. LINK
  50. Barreda DR, Hanington PC, Walsh CK, Wong P, Belosevic M* (2004) Differentially expressed genes that encode potential markers of goldfish macrophage development in vitro. Developmental and Comparative Immunology 28(7-8): 727-746. LINK
  51. Barreda DR, Hanington PC, Belosevic M* (2004) Regulation of myeloid development and function by colony stimulating factors. Developmental and Comparative Immunology 28(5): 509-554. LINK
  52. Barreda DR* (2002) ATP synthase: structural changes that couple DmH+ to ATP synthesis. Crossing Boundaries (eJournal of the Graduate Students’ Association, University of Alberta). 1(2): 99-111. LINK
  53. Barreda DR, Belosevic M* (2001) Transcriptional regulation of hematopoiesis. Developmental and Comparative Immunology 25 (8-9): 763-789. LINK
  54. Neumann NF, Stafford JL, Barreda DR, Ainsworth AJ, Belosevic M* (2001) Antimicrobial mechanisms of fish phagocytes and their role in host defense. Developmental and Comparative Immunology 25 (8-9): 807-825. LINK
  55. Barreda DR, Belosevic M* (2001) Characterization of growth enhancing factor production in different phases of in vitro fish macrophage development. Fish and Shellfish Immunology 11: 169-186. LINK
  56. Barreda DR, Neumann NF, Belosevic M* (2000) Flow cytometric analysis of PKH26-labeled goldfish kidney-derived macrophages. Developmental and Comparative Immunology 24(4): 395-406. [IF: 3.290]. LINK
  57. Neumann NF, Barreda DR, Belosevic M* (2000) Generation and functional analysis of distinct macrophage sub-populations from goldfish (Carassius auratus) kidney leukocyte cultures. Fish and Shellfish Immunology 10 (1): 1-20. LINK
  58. Ausio J*, Soley JT, Burger W, Lewis JD, Barreda D, Cheng KM (1999) The histidine-rich protamine from ostrich and tinamou sperm. A link between reptile and bird protamines. Biochemistry 38 (1): 180-184. LINK
  59. Neumann NF, Barreda D, Belosevic M* (1998) Production of a macrophage growth factor(s) by a macrophage cell line and macrophages derived from goldfish kidney leukocytes. Developmental and Comparative Immunology 22 (4): 417-432. LINK
  60. Ausio J*, Van Veghel MLJ, Gomez R, Barreda D (1997) The sperm nuclear basic proteins (SNBPs) of the sponge Neofibularia nolitangere: implications for the molecular evolution of SNBPs. Journal of Molecular Evolution 45: 91-96. LINK


Invited Book Chapters – Refereed


  1. Barreda DR*, Neely HR, Flajnik MF*. (2016) Evolution of myeloid cells. In: Myeloid cells in health and disease: A synthesis. Editor: Siamon Gordon (Oxford). ASM Press, UK. pp 1-13.
  2. Rieger AM, Barreda DR*. (2015) Accurate assessment of cell death by imaging flow cytometry. In: Imaging Flow Cytometry: Methods and Protocols. Editor: Natasha Barteneva and Ivan A. Vorobjev. Humana Press, USA (part of the Springer publishing group). p.209-220.
  3. Barreda DR*, Rieger AM, Girard NC, Clarahan SDG, Eleyinmi AF (2009) Comparative immunology-based approaches to veterinary diseases, in Animal and Plant Productivity, [Ed. Robert J.Hudson], in Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, EOLSS Publishers, Oxford, UK.