Waskiewicz Laboratory Publications:


PUBMED link for Waskiewicz Papers

Peer-Reviewed Manuscripts (my trainees underlined, **BOLD Waskiewicz)

  1. Liu, C.*, Widen, S.*, Williamson, K.A., Ratnapriya, R., Gerth-Kahlert, C., Rainger, J., Alur, R.P., Strachan, E., Manjunath, S.H., Balakrishnan, A., Floyd, J.A., UK10K Consortium, Li, T., Waskiewicz, A.J., Brooks, B., Lehmann, O.J., Fitzpatrick, D.R., and Swaroop, A. (in press) A Secreted WNT-Ligand Binding Domain of FZD5 Generated by a Frameshift Mutations Causes Autosomal Dominant Coloboma. Human Molecular Genetics, in press. *co-first author; Waskiewicz is co-corresponding author.
  2. French, C.R., Seshadri, S., Destefano, A.L., Fornage, M., Arnold, C.R., Gage, P.J., Skarie, J.M., Dobyns, W.B., Millen, K.J., Liu, T., Dietz, W., Kume, T., Hofker, M., Emery, D.J., Childs, S.J., Waskiewicz, A.J., and Lehmann, O.J. (2014) Mutation of FOXC1 and PITX2 induces cerebral small vessel disease. Journal of Clinical Investigation 124: 4877-81.
  3. Holly, V., Widen, S.A., Famulski, J.K., and Waskiewicz, A.J. (2014) Sfrp1a and Sfrp5 positively regulate BMP and Wnt signaling during retinal development. Developmental Biology 388: 192-204.
  4. Drummond, D., Cheng, C., Selland, L.G., grad, J.C., Prichard, L.B., and Waskiewicz, A.J. (2013) The role of Zic transcription factors in regulating hindbrain retinoic acid signaling. BMC Developmental Biology 13:31.
  5. French, C.R., Stach, T.R., March, L.D. Lehmann, O.J., Waskiewicz, A.J. (2013) Apoptotic and proliferative defects characterize ocular development in a colobomatous microphthalmic BMP model. IOVS, 54 (7) 4636-47.
  6. Pant, S.D., March, L.D., French, C.R., Famulski, J.K., Waskiewicz, A.J., Lehmann, O.J. (2013) Molecular mechanisms regulating ocular apoptosis in zebrafish gdf6a mutants. IOVS, 54 (8) 5871-9.
  7. Asai-Coakwell, M., March, L., Dai, X.H., DuVal, M., Lopez, I., French, C.R., Famulski, J., De Baere, E., Francis, P.J., Sundaresan, P., Sauve, Y., Koenekoop, R.K., Berry, F.B., Allison, W.T., Waskeiwicz, A.J., and Lehmann, O.J. (2013) Contribution of Growth Differentiation Factor 6 dependent cell survival to early onset retinal dystrophies. Human Molecular Genetics, 22:1432-42.
  8. Pillay, L.M., Selland, L.G., Fleisch, V.C., Leighton, P.L.A., Cheng, C.S., Famulski, J.K., Ritzel, R.G., March, L.D., Wang, H., Allison, W.T.A., and Waskiewicz, A.J. (2013) Evaluating the mutagenic activity of targeted endonucleases containing the Sharkey FokI cleavage domain variant in zebrafish. Zebrafish 10: 353-64.
  9. Fleisch, V.C., Leighton, P.L.A., Wang, H., Pillay, L.M., Ritzel, R.G., Binder, G., Birbickram, R., Tierney, K., Ali, D.W., Waskeiwicz, A.J., and Allison, W.T.A. (2013) Targeted Mutation of the Gene Encoding Prion Protein in Zebrafish reveals a Conserved Role in Neuron Excitability. Neurobiology of Disease 55: 11-2.
  10.  Gongal P, March L, Holly VL, Pillay LM, Berry-Wynne K, Kagechika H and Waskiewicz (2011) Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning. Developmental Biology 355: 55-64. [Impact factor 4.1; rank 7/38 in developmental biology]
  11. Lukowski CM, Drummond DD and Waskiewicz AJ. (2011) Pbx dependent regulation of lbx gene expression in developing zebrafish embryos. Genome 54: 973-85 [Impact factor 1.7; rank 113/156 in genetics/heredity]
  12. Erickson TE, Pillay LM and Waskiewicz AJ. (2011) Zebrafish Tshz3b negatively regulates Hox function in the developing hindbrain. Genesis 49: 725-42. [Impact factor 2.4; rank 24/38 in developmental biology]
  13. Erickson TE, French CR and Waskiewicz AJ. (2010) Meis1 specifies positional information in the retina and tectum to organize the zebrafish visual system. Neural Development Sep 1, 5:22. [Impact Factor 3.4; Rank 9/38 in Developmental Biology]
  14. Pillay LM, Forrester AM, Erickson TE, Berman J and Waskiewicz AJ. (2010) The Hox cofactors Meis1 and Pbx act upstream of gata1 to promote primitive hematopoiesis. Developmental Biology 340: 306-317. [Impact Factor 4.1; Rank 7/38 in Developmental Biology]
  15. Ye M, Berry-Wynne K, Asai-Coakwell M, Sundaresan P, Footz T, French CR, Abitbol M, Fleisch V, Corbett N, Allison T, Walter M, Underhill TM, Waskiewicz AJ and Lehmann OJ. (2010) Mutation of the Bone Morphogenetic Protein GDF3 causes ocular and skeletal anomalies. Human Molecular Genetics 19: 287-298. [Impact Factor 8.1; Rank 13/156 in Genetics and Heredity]
  16. French CR, Erickson T, French DV, Pilgrim DB and Waskiewicz AJ. (2009) Gdf6a is required for the initiation of dorsal-ventral retinal patterning and lens development. Devolpmental Biology 333: 37-47. [Impact Factor 4.1; Rank 7/38 in Developmental Biology]
  17. Asai-Coakwell M, French CR, Ye M, Garcha K, Bigot K, Perera AG, Staehling-Hampton K, Mema SC, Chanda B, Mushegian A, Bamforth S, Doschak MR, Li G, Dobbs MB, Giampietro PF, Brooks BP, Vijayalakshmi P, Sauvé Y, Abitbol M, Sundaresan P, van Heyningen V, Pourquié O, Underhill TM, Waskiewicz AJ and Lehmann OJ. (2009) Incomplete penetrance and phenotypic variability characterize Gdf6-attributable oculo-skeletal phenotypes. Human Molecular Genetics. 18(6):1110-21. [Impact Factor 8.1; Rank 13/156 in Genetics and Heredity]
  18. Gongal PA and Waskiewicz, AJ. (2008) Zebrafish model of holoprosencephaly demonstrates a key role for TGIF in regulating retinoic acid metabolism. Human Molecular Genetics 17, 525-38. [Impact Factor 8.1, rank 11/131 = 8.4% in genetics and heredity]
  19. Hanington P, Shunmoogum AP, Reaume L, Waskiewicz AJ, Belosevic M and Ali, DP. (2008) Analysis of leukemia inhibitory factor and leukemia inhibitory factor receptor in embryonic and adult zebrafish (Danio rerio). Developmental Biology 314, 250-260. [Impact Factor 5.2, rank 7/34 = 21.2% in Developmental Biology]
  20. Kohli V, Robles V, Cancela ML, Acker JP, Waskiewicz AJ and Elezzabi AY. (2007) An alternative method for delivering exogenous material into developing zebrafish embryos. Biotechnology and Bioengineering 98, 1230-41. [Impact Factor 2.5, rank 43/139 = 30.9% in Biotechnology and Applied Microbiology]
  21. Maves L, Waskiewicz AJ, Paul B, Cao Y, Tyler A, Moens CB, and Tapscott SJ. (2007) Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation. Development 134, 3371-82. [Impact Factor 7.7, rank 5/34 = 14.7% in Developmental Biology]
  22. French CR, Erickson TE, Callander D, Berry KM, Koss R, Hagey DW, Stout J, Wuennenberg-Stapleton K, Ngai J, Moens CB and AJ Waskiewicz. (2007) Pbx homeodomain proteins pattern both the zebrafish retina and tectum BMC Developmental Biology 7, 1-12. [Impact Factor 5.4, rank 6/34 = 17.6% in Developmental Biology]
  23. Asai-Coakwell M*, French CR*, Berry K, Ye M, Koss R, Somerville M, Mueller R, van Heyningen V, Waskiewicz AJ and OJ Lehmann. (2007) GDF6, a novel locus for a spectrum of ocular developmental anomalies. American Journal of Human Genetics 80, 306-315. * denotes equal authors [Impact factor 12.6, rank 6/131 = 4.6% in Genetics and Heredity]
  24. Erickson TE, Scholpp S, Brand M, Moens CB and Waskiewicz AJ. (2007) Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries. Developmental Biology 301, 504-517. [Impact Factor = 5.2, rank 7/34 = 21.2% in Developmental Biology]
  25. Lukowski CM, Ritzel RG and Waskiewicz AJ. (2006) Expression of two insm1-like genes in the developing nervous system. Gene Expression Patterns 6, 711-18. [Impact Factor 2.0, rank 81/131 = 61.8% in Genetics and Heredity]
  26. Manning AG, Crawford BC, Waskiewicz AJ and Pilgrim DP. (2004) unc-119 homolog required for normal development of the zebrafish nervous system. Genesis 40, 223-30. [Impact Factor 2.6, rank 64/131 = 48.9%]
  27. Orton KC, Ling J, Waskiewicz AJ, Cooper JA, Merrick WC, Rhoads RE, Sonenberg N and Traugh JA. (2004) Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. Journal of Biological Chemistry 279, 38649-57. [Impact Factor 5.8, rank 39/262 = 14.9%]
  28. Waskiewicz AJ, Rikhof HR and Moens CB. (2002) Eliminating zebrafish Pbx proteins reveals a hindbrain ground state. Developmental Cell 3, 723-733. [Impact factor = 13.5; rank 3/34 = 8.8% in Developmental Biology]
  29. Waskiewicz AJ, Rikhof HR, Hernandez RE and Moens CB. (2001) Vertebrate Meis functions to stabilize Pbx proteins and regulate hindbrain patterning. Development 128, 4139-4151. [Impact Factor = 8.6, rank 3/33 = 9.1%]
  30. Waskiewicz AJ, Johnson JC, Penn B, Mahalingam M, Kimball SR and Cooper JA. (1999) Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. Mol Cell Biol. 19, 1871-80. [Impact Factor = 9.8; rank 17/308 = 5.5% in Biochemistry and Molecular Biology]
  31. Wang X, Flynn A, Waskiewicz AJ, Webb BL, Vries RG, Baines IA, Cooper JA and Proud CG. (1998) The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways. J Biol Chem. 273, 9373-77. [Impact factor = 7.3, rank 29/308 = 9.4% in Biochemistry and Molecular Biology]
  32. Waskiewicz AJ, Flynn A, Proud CG and Cooper JA. (1997) Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J. 16, 1909-20. [Impact Factor = 12.5, rank 12/308 = 3.9 % in Biochemistry and Molecular Biology]
  33. Waskiewicz AJ and Cooper JA. (1993) Evolutionary conservation of Xenopus laevis mitogen-activated protein kinase activation and function. Cell Growth Differ. 4, 965-73. [Impact Factor = 3.7, rank 71/308 = 23% in Biochemistry and Molecular Biology]


  1. Gongal PA, French CR and Waskiewicz AJ. (2011) Aberrant Forebrain Signaling During Early Development Underlies the Generation of Holoprosencephaly and Coloboma. Biochim Biophys Acta. 1812: 390-401.
  2. French CR and Waskiewicz AJ. (2009) Use of zebrafish forward genetic screens to uncover novel regulators of the vertebrate nervous system. Encyclopedia of Neuroscience. Published by Springer (edited by Binder).
  3. Waskiewicz AJ and Cooper JA. (1995) Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr Opin Cell Biol. 7:798-805.